Synthesis and initial evaluation of quinoline-based inhibitors of the SH2-containing inositol 5′-Phosphatase (SHIP)

Recently, inhibition of the SH2-containing inositol 5′-phosphatase 1 (SHIP1) has become an attractive strategy for facilitating engraftment of MHC-I mismatched bone marrow grafts, increasing the number of adult stem cells in vivo, and inducing mobilization of hematopoietic stem cells. Utilizing high...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Russo, Christopher M., Adhikari, Arijit A., Wallach, Daniel R., Fernandes, Sandra, Balch, Amanda N., Kerr, William G., Chisholm, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4628863/
https://ncbi.nlm.nih.gov/pubmed/26453006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.09.034
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