Germinal center hypoxia potentiates immunoglobulin class switch recombination

Germinal centers (GCs) are anatomic sites where B cells undergo secondary diversification to produce high affinity, class switched antibodies. We hypothesized that proliferating B cells in GCs create a hypoxic microenvironment that governs their further differentiation. Using molecular markers, we f...

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Bibliografiset tiedot
Julkaisussa:J Immunol
Päätekijät: Abbott, Robert K., Thayer, Molly, Labuda, Jasmine, Silva, Murillo, Philbrook, Phaethon, Cain, Derek W., Kojima, Hidefumi, Hatfield, Stephen, Sethumadhavan, Shalini, Ohta, Akio, Reinherz, Ellis L., Kelsoe, Garnett, Sitkovsky, Michail
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123804/
https://ncbi.nlm.nih.gov/pubmed/27798169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601401
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