Immunological mechanisms of the antitumor effects of supplemental oxygenation

Antitumor T cells either avoid or are inhibited in hypoxic and extracellular adenosine-rich tumor microenvironments (TMEs) by A2A adenosine receptors. This may limit further advances in cancer immunotherapy. There is a need for readily available and safe treatments that weaken the hypoxia–A2-adenosi...

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Gepubliceerd in:Sci Transl Med
Hoofdauteurs: Hatfield, Stephen M., Kjaergaard, Jorgen, Lukashev, Dmitriy, Schreiber, Taylor H., Belikoff, Bryan, Abbott, Robert, Sethumadhavan, Shalini, Philbrook, Phaethon, Ko, Kami, Cannici, Ryan, Thayer, Molly, Rodig, Scott, Kutok, Jeffrey L., Jackson, Edwin K., Karger, Barry, Podack, Eckhard R., Ohta, Akio, Sitkovsky, Michail V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641038/
https://ncbi.nlm.nih.gov/pubmed/25739764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa1260
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