Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes

Rapidly evolving pathogens such as HIV or influenza can quickly mutate their antigenic profiles, reducing the efficacy of conventional vaccines. Despite this challenge, functionally required epitopes are highly conserved among heterologous viral strains and represent a key vulnerability that could b...

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Vydáno v:Cell Rep
Hlavní autoři: Silva, Murillo, Nguyen, Thao H., Philbrook, Phaethon, Chu, Matthew, Sears, Olivia, Hatfield, Stephen, Abbott, Robert K., Kelsoe, Garnett, Sitkovsky, Michail V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771444/
https://ncbi.nlm.nih.gov/pubmed/29281817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.12.014
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