Outflanking immunodominance to target subdominant broadly neutralizing epitopes

A major obstacle to vaccination against antigenically variable viruses is skewing of antibody responses to variable immunodominant epitopes. For influenza virus hemagglutinin (HA), the immunodominance of the variable head impairs responses to the highly conserved stem. Here, we show that head immuno...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Angeletti, Davide, Kosik, Ivan, Santos, Jefferson J. S., Yewdell, William T., Boudreau, Carolyn M., Mallajosyula, Vamsee V. A., Mankowski, Madeleine C., Chambers, Michael, Prabhakaran, Madhu, Hickman, Heather D., McDermott, Adrian B., Alter, Galit, Chaudhuri, Jayanta, Yewdell, Jonathan W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612916/
https://ncbi.nlm.nih.gov/pubmed/31213541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816300116
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