Outflanking immunodominance to target subdominant broadly neutralizing epitopes

A major obstacle to vaccination against antigenically variable viruses is skewing of antibody responses to variable immunodominant epitopes. For influenza virus hemagglutinin (HA), the immunodominance of the variable head impairs responses to the highly conserved stem. Here, we show that head immuno...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Angeletti, Davide, Kosik, Ivan, Santos, Jefferson J. S., Yewdell, William T., Boudreau, Carolyn M., Mallajosyula, Vamsee V. A., Mankowski, Madeleine C., Chambers, Michael, Prabhakaran, Madhu, Hickman, Heather D., McDermott, Adrian B., Alter, Galit, Chaudhuri, Jayanta, Yewdell, Jonathan W.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2019
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612916/
https://ncbi.nlm.nih.gov/pubmed/31213541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816300116
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires