Outflanking immunodominance to target subdominant broadly neutralizing epitopes

A major obstacle to vaccination against antigenically variable viruses is skewing of antibody responses to variable immunodominant epitopes. For influenza virus hemagglutinin (HA), the immunodominance of the variable head impairs responses to the highly conserved stem. Here, we show that head immuno...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Angeletti, Davide, Kosik, Ivan, Santos, Jefferson J. S., Yewdell, William T., Boudreau, Carolyn M., Mallajosyula, Vamsee V. A., Mankowski, Madeleine C., Chambers, Michael, Prabhakaran, Madhu, Hickman, Heather D., McDermott, Adrian B., Alter, Galit, Chaudhuri, Jayanta, Yewdell, Jonathan W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2019
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612916/
https://ncbi.nlm.nih.gov/pubmed/31213541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816300116
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