Outflanking immunodominance to target subdominant broadly neutralizing epitopes

A major obstacle to vaccination against antigenically variable viruses is skewing of antibody responses to variable immunodominant epitopes. For influenza virus hemagglutinin (HA), the immunodominance of the variable head impairs responses to the highly conserved stem. Here, we show that head immuno...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Angeletti, Davide, Kosik, Ivan, Santos, Jefferson J. S., Yewdell, William T., Boudreau, Carolyn M., Mallajosyula, Vamsee V. A., Mankowski, Madeleine C., Chambers, Michael, Prabhakaran, Madhu, Hickman, Heather D., McDermott, Adrian B., Alter, Galit, Chaudhuri, Jayanta, Yewdell, Jonathan W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2019
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612916/
https://ncbi.nlm.nih.gov/pubmed/31213541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816300116
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