Structural Basis for Different Substrate Profiles of Two Closely Related Class D β-lactamases and Their Inhibition by Halogens

OXA-163 and OXA-48 are closely related class D β-lactamases that exhibit different substrate profiles. OXA-163 hydrolyzes oxyimino-cephalosporins, particularly ceftazidime, while OXA-48 prefers carbapenem substrates. OXA-163 differs from OXA-48 by one substitution (S212D) in the active site β5-stran...

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Publicado no:Biochemistry
Main Authors: Stojanoski, Vlatko, Chow, Dar-Chone, Fryszczyn, Bartlomiej, Hu, Liya, Nordmann, Patrice, Poirel, Laurent, Sankaran, Banumathi, Prasad, B. V. Venkataram, Palzkill, Timothy
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123777/
https://ncbi.nlm.nih.gov/pubmed/25938261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00298
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