The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M β-lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation

β-Lactamases are enzymes produced by bacterial cells that provide resistance to β-lactam antibiotics. The CTX-M class of β-lactamases provides resistance against the antibiotic, cefotaxime, but not a related oxyimino-cephalosporin antibiotic, ceftazidime. β-lactamases that carry the P167S substituti...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Biochemistry
Huvudupphovsmän: Patel, Meha P., Hu, Liya, Stojanoski, Vlatko, Sankaran, Banumathi, Venkataram Prasad, B. V., Palzkill, Timothy
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645026/
https://ncbi.nlm.nih.gov/pubmed/28613873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00176
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk