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The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M β-lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation
β-Lactamases are enzymes produced by bacterial cells that provide resistance to β-lactam antibiotics. The CTX-M class of β-lactamases provides resistance against the antibiotic, cefotaxime, but not a related oxyimino-cephalosporin antibiotic, ceftazidime. β-lactamases that carry the P167S substituti...
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| Publicado en: | Biochemistry |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5645026/ https://ncbi.nlm.nih.gov/pubmed/28613873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00176 |
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