DNA Targeting as a Likely Mechanism Underlying the Antibacterial Activity of Synthetic Bis-Indole Antibiotics

We previously reported the synthesis and biological activity of a series of cationic bis-indoles with potent, broad-spectrum antibacterial properties. Here, we describe mechanism of action studies to test the hypothesis that these compounds bind to DNA and that this target plays an important role in...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Opperman, Timothy J., Kwasny, Steven M., Li, Jessica Bo, Lewis, Mark A., Aiello, Daniel, Williams, John D., Peet, Norton P., Moir, Donald T., Bowlin, Terry L., Long, Eric C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118985/
https://ncbi.nlm.nih.gov/pubmed/27620482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00309-16
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