Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090

The prevalence of drug-resistant bacteria in the clinic has propelled a concerted effort to find new classes of antibiotics that will circumvent current modes of resistance. We have previously described a set of bisamidine antibiotics that contains a core composed of two indoles and a central linker...

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Main Authors: Williams, John D., Nguyen, Son T., Gu, Shen, Ding, Xiaoyuan, Butler, Michelle M., Tashjian, Tommy F., Opperman, Timothy J., Panchal, Rekha G., Bavari, Sina, Peet, Norton P., Moir, Donald T., Bowlin, Terry L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906850/
https://ncbi.nlm.nih.gov/pubmed/24239389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.10.014
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