Comparative In Vitro Activity Profiles of Novel Bis-Indole Antibacterials against Gram-Positive and Gram-Negative Clinical Isolates

Antimicrobial susceptibilities of 233 Gram-positive and 180 Gram-negative strains to two novel bis-indoles were evaluated. Both compounds were potent inhibitors of Gram-positive bacteria, with MIC(90) values of 0.004 to 0.5 μg/ml. One bis-indole, MBX 1162, exhibited potent activity against all Gram-...

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Main Authors: Butler, Michelle M., Williams, John D., Peet, Norton P., Moir, Donald T., Panchal, Rekha G., Bavari, Sina, Shinabarger, Dean L., Bowlin, Terry L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Susceptibility
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934966/
https://ncbi.nlm.nih.gov/pubmed/20625154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00484-10
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