DNA Targeting as a Likely Mechanism Underlying the Antibacterial Activity of Synthetic Bis-Indole Antibiotics

We previously reported the synthesis and biological activity of a series of cationic bis-indoles with potent, broad-spectrum antibacterial properties. Here, we describe mechanism of action studies to test the hypothesis that these compounds bind to DNA and that this target plays an important role in...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Opperman, Timothy J., Kwasny, Steven M., Li, Jessica Bo, Lewis, Mark A., Aiello, Daniel, Williams, John D., Peet, Norton P., Moir, Donald T., Bowlin, Terry L., Long, Eric C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2016
Konular:
Mechanisms of Action: Physiological Effects
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118985/
https://ncbi.nlm.nih.gov/pubmed/27620482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00309-16
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller