Mutations in the Pseudomonas aeruginosa Needle Protein Gene pscF Confer Resistance to Phenoxyacetamide Inhibitors of the Type III Secretion System

The type III secretion system (T3SS) is a clinically important virulence mechanism in Pseudomonas aeruginosa that secretes and translocates effector toxins into host cells, impeding the host's rapid innate immune response to infection. Inhibitors of T3SS may be useful as prophylactic or adjunct...

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Detalhes bibliográficos
Main Authors: Bowlin, Nicholas O., Williams, John D., Knoten, Claire A., Torhan, Matthew C., Tashjian, Tommy F., Li, Bing, Aiello, Daniel, Mecsas, Joan, Hauser, Alan R., Peet, Norton P., Bowlin, Terry L., Moir, Donald T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023729/
https://ncbi.nlm.nih.gov/pubmed/24468789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02795-13
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