Synthesis and structure-activity relationships of novel phenoxyacetamide inhibitors of the Pseudomonas aeruginosa type III secretion system (T3SS)

The increasing prevalence of drug-resistant bacterial infections is driving the discovery and development not only of new antibiotics, but also of inhibitors of virulence factors that are crucial for in vivo pathogenicity. One such virulence factor is the type III secretion system (T3SS), which play...

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Détails bibliographiques
Publié dans:Bioorg Med Chem
Auteurs principaux: Williams, John D., Torhan, Matthew C., Neelagiri, Venu, Brown, Carson, Bowlin, Nicholas O., Di, Ming, McCarthy, Courtney T., Aiello, Daniel, Peet, Norton P., Bowlin, Terry L., Moir, Donald T.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339527/
https://ncbi.nlm.nih.gov/pubmed/25638499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.01.011
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