Synthesis and structure-activity relationships of novel phenoxyacetamide inhibitors of the Pseudomonas aeruginosa type III secretion system (T3SS)

The increasing prevalence of drug-resistant bacterial infections is driving the discovery and development not only of new antibiotics, but also of inhibitors of virulence factors that are crucial for in vivo pathogenicity. One such virulence factor is the type III secretion system (T3SS), which play...

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Gepubliceerd in:Bioorg Med Chem
Hoofdauteurs: Williams, John D., Torhan, Matthew C., Neelagiri, Venu, Brown, Carson, Bowlin, Nicholas O., Di, Ming, McCarthy, Courtney T., Aiello, Daniel, Peet, Norton P., Bowlin, Terry L., Moir, Donald T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339527/
https://ncbi.nlm.nih.gov/pubmed/25638499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.01.011
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