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Synthesis and Biological Evaluation of Botulinum Neurotoxin A Protease Inhibitors
NSC 240898 was previously identified as a botulinum neurotoxin A light chain (BoNT/A LC) endopeptidase inhibitor by screening the National Cancer Institute Open Repository diversity set. Two types of analogs have been synthesized and shown to inhibit BoNT/A LC in a FRET-based enzyme assay, with conf...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2841792/ https://ncbi.nlm.nih.gov/pubmed/20155918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901852f |
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