Synthesis and Biological Evaluation of Botulinum Neurotoxin A Protease Inhibitors

NSC 240898 was previously identified as a botulinum neurotoxin A light chain (BoNT/A LC) endopeptidase inhibitor by screening the National Cancer Institute Open Repository diversity set. Two types of analogs have been synthesized and shown to inhibit BoNT/A LC in a FRET-based enzyme assay, with conf...

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Detalhes bibliográficos
Main Authors: Li, Bing, Pai, Ramdas, Cardinale, Steven C., Butler, Michelle M., Peet, Norton P., Moir, Donald T., Bavari, Sina, Bowlin, Terry L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841792/
https://ncbi.nlm.nih.gov/pubmed/20155918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901852f
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