Coumarin-based Inhibitors of Bacillus anthracis and Staphylococcus aureus Replicative DNA Helicase: Chemical Optimization, Biological Evaluation, and Antibacterial Activities

The increasing prevalence of drug-resistant bacterial infections demands the development of new antibacterials that are not subject to existing mechanisms of resistance. Previously, we described coumarin-based inhibitors of an underexploited bacterial target, namely, the replicative helicase. Here w...

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Detalhes bibliográficos
Main Authors: Li, Bing, Pai, Ramdas, Di, Ming, Aiello, Daniel, Barnes, Marjorie H., Butler, Michelle M., Tashjian, Tommy F., Peet, Norton P., Bowlin, Terry L., Moir, Donald T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531573/
https://ncbi.nlm.nih.gov/pubmed/23231076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300922h
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