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Synthesis and antifungal evaluation of head-to-head and head-to-tail bisamidine compounds

Herein, we describe the antifungal evaluation of 43 bisamidine compounds, of which 26 are new, having the scaffold [Am]-[HetAr]-[linker]-[HetAr]-[Am], in which [Am] is a cyclic or acyclic amidine group, [linker] is a benzene, pyridine, pyrimidine, pyrazine ring, or an aliphatic chain of two to four...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Nguyen, Son T., Kwasny, Steven M., Ding, Xiaoyuan, Williams, John D., Peet, Norton P., Bowlin, Terry L., Opperman, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554983/
https://ncbi.nlm.nih.gov/pubmed/26209266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.07.006
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