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Structure-Activity Relationships of a Novel Pyranopyridine Series of Gram-negative Bacterial Efflux Pump Inhibitors

Recently we described a novel pyranopyridine inhibitor (MBX2319) of RND-type efflux pumps of the Enterobacteriaceae. MBX2319 (3,3-dimethyl-5-cyano-8-morpholino-6-(phenethylthio)-3,4-dihydro-1H-pyrano[3,4-c]pyridine) is structurally distinct from other known Gram-negative efflux pump inhibitors (EPIs...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Bioorg Med Chem
Egile Nagusiak: Nguyen, Son T., Kwasny, Steven M., Ding, Xiaoyuan, Cardinale, Steven C., McCarthy, Courtney T., Kim, Hong-Suk, Nikaido, Hiroshi, Peet, Norton P., Williams, John D., Bowlin, Terry L., Opperman, Timothy J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398657/
https://ncbi.nlm.nih.gov/pubmed/25818767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.03.016
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