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When Is It Important to Measure Unbound Drug in Evaluating Nanomedicine Pharmacokinetics?

Nanoformulations have become important tools for modifying drug disposition, be it from the perspective of enabling prolonged drug release, protecting the drug molecule from metabolism, or achieving targeted delivery. When examining the in vivo pharmacokinetic properties of these formulations, most...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Drug Metab Dispos
Hauptverfasser: Stern, Stephan T., Martinez, Marilyn N., Stevens, David M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118636/
https://ncbi.nlm.nih.gov/pubmed/27670412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.073148
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