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A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca(2+) permeation and SOCE-induced gene transcription

The Ca(2+) release-activated Ca(2+) channel mediates Ca(2+) influx in a plethora of cell types, thereby controlling diverse cellular functions. The channel complex is composed of STIM1, an endoplasmic reticulum Ca(2+) sensing protein and Orai1, a plasma membrane Ca(2+) channel. Channels composed of...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Frischauf, Irene, Zayats, Vasilina, Deix, Michael, Hochreiter, Anna, Polo, Isaac Jardin, Muik, Martin, Lackner, Barbara, Svobodová, Barbora, Pammer, Teresa, Litviňuková, Monika, Sridhar, Amrutha Arumbakam, Derler, Isabella, Bogeski, Ivan, Romanin, Christoph, Ettrich, Rüdiger H., Schindl, Rainer
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117258/
https://ncbi.nlm.nih.gov/pubmed/26696631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aab1901
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