Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription

The channel Orai1 requires Ca(2+) store depletion in the endoplasmic reticulum and an interaction with Ca(2+) sensor STIM1 to mediate Ca(2+) signaling. Alterations in Orai1-mediated Ca(2+) influx have been linked to several pathological conditions including immunodeficiency, tubular myopathy, and ca...

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Publicado no:Sci Signal
Main Authors: Frischauf, Irene, Litviňuková, Monika, Schober, Romana, Zayats, Vasilina, Svobodová, Barbora, Bonhenry, Daniel, Lunz, Victoria, Cappello, Sabrina, Tociu, Laura, Reha, David, Stallinger, Amrutha, Hochreiter, Anna, Pammer, Teresa, Butorac, Carmen, Muik, Martin, Groschner, Klaus, Bogeski, Ivan, Ettrich, Rüdiger H., Romanin, Christoph, Schindl, Rainer
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433236/
https://ncbi.nlm.nih.gov/pubmed/29184031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aao0358
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