Cholesterol modulates Orai1 channel function

STIM1 (stromal interaction molecule 1) and Orai proteins are the essential components of Ca(2+) release–activated Ca(2+) (CRAC) channels. We focused on the role of cholesterol in the regulation of STIM1-mediated Orai1 currents. Chemically induced cholesterol depletion enhanced store-operated Ca(2+)...

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Publicat a:Sci Signal
Autors principals: Derler, Isabella, Jardin, Isaac, Stathopulos, Peter B., Muik, Martin, Fahrner, Marc, Zayats, Vasilina, Pandey, Saurabh K., Poteser, Michael, Lackner, Barbara, Absolonova, Marketa, Schindl, Rainer, Groschner, Klaus, Ettrich, Rüdiger, Ikura, Mitsu, Romanin, Christoph
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373433/
https://ncbi.nlm.nih.gov/pubmed/26814231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aad7808
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