Givinostat, a type II histone deacetylase inhibitor, induces potent caspase-dependent apoptosis in human lymphoblastic leukemia

Unlike chronic myeloid leukemia, patients with acute lymphoblastic leukemia (ALL) with Philadelphia chromosome (Ph+) do not respond well to Imatinib or tyrosine kinase inhibitors (TKI). In addition, TKI might induce resistant mutations in kinase domain (KD) of ABL in patients with relapsed diseases....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Genes Cancer
Egile Nagusiak: Li, Ying, Zhao, Kevin, Yao, Chenjiao, Kahwash, Samir, Tang, Yan, Zhang, Guojiuan, Patterson, Kara, Wang, Qi-En, Zhao, Weiqiang
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2016
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115170/
https://ncbi.nlm.nih.gov/pubmed/28050230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/genesandcancer.117
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