Histone deacetylase inhibitors induce apoptosis in myeloid leukemia by suppressing autophagy

Histone deacetylase (HDAC)-inhibitors (HDACis) are well characterized anti-cancer agents with promising results in clinical trials. However, mechanistically little is known regarding their selectivity in killing malignant cells while sparing normal cells. Gene expression-based chemical genomics iden...

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Main Authors: Stankov, Metodi V., Khatib, Mona El, Thakur, Basant Kumar, Heitmann, Kirsten, Panayotova-Dimitrova, Diana, Schoening, Jennifer, Bourquin, Jean-Pierre, Schweitzer, Nora, Leverkus, Martin, Welte, Karl, Reinhardt, Dirk, Li, Zhe, Orkin, Stuart H., Behrens, Georg M.N., Klusmann, Jan-Henning
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947652/
https://ncbi.nlm.nih.gov/pubmed/24080946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.264
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