Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells

FK866 is a specific inhibitor of NAMPT and induces apoptosis of leukemic cells by depletion of intracellular NAD(+). Since up-regulation of NAMPT is associated with several cases of cancers, including leukemias, we asked whether in leukemic cells inhibition of NAMPT involves p53 pathway. We observed...

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Hlavní autoři: Thakur, Basant Kumar, Dittrich, Tino, Chandra, Prakash, Becker, Annette, Kuehnau, Wolfgang, Klusmann, Jan-Henning, Reinhardt, Dirk, Welte, Karl
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley Subscription Services, Inc., A Wiley Company 2013
Témata:
Carcinogenesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562481/
https://ncbi.nlm.nih.gov/pubmed/22815158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27726
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