Farnesiferol C Induces Apoptosis in Chronic Myelogenous Leukemia Cells as an Imatinib Sensitizer via Caspase Activation and HDAC (Histone Deacetylase) Inactivation

Herein the underlying apoptotic mechanism of Farnesiferol C (FC) derived from Ferula assafoetida was elucidated in chronic myelogenous leukemia (CML) K562 and KBM5 cells. FC showed significant cytotoxicity in K562 and KBM5 cells, more so than in U937 and UL-60 acute myeloid leukemia (AML) cells. Cle...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Jung, Ji Hoon, Park, Ji Eon, Sim, Deok Yong, Im, Eunji, Park, Woon Yi, Lee, Duckgue, Shim, Bum-Sang, Kim, Sung-Hoon
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6888363/
https://ncbi.nlm.nih.gov/pubmed/31698777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20225535
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