Givinostat, a type II histone deacetylase inhibitor, induces potent caspase-dependent apoptosis in human lymphoblastic leukemia

Unlike chronic myeloid leukemia, patients with acute lymphoblastic leukemia (ALL) with Philadelphia chromosome (Ph+) do not respond well to Imatinib or tyrosine kinase inhibitors (TKI). In addition, TKI might induce resistant mutations in kinase domain (KD) of ABL in patients with relapsed diseases....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genes Cancer
Prif Awduron: Li, Ying, Zhao, Kevin, Yao, Chenjiao, Kahwash, Samir, Tang, Yan, Zhang, Guojiuan, Patterson, Kara, Wang, Qi-En, Zhao, Weiqiang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2016
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115170/
https://ncbi.nlm.nih.gov/pubmed/28050230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/genesandcancer.117
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