Discovery of Clinically Approved Agents That Promote Suppression of Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations

Rationale: Premature termination codons (PTCs) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF). Several agents are known to suppress PTCs but are poorly efficacious or toxic. Objectives: To determine whether there are clinically available agents that...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Mutyam, Venkateshwar, Du, Ming, Xue, Xiaojiao, Keeling, Kim M., White, E. Lucile, Bostwick, J. Robert, Rasmussen, Lynn, Liu, Bo, Mazur, Marina, Hong, Jeong S., Falk Libby, Emily, Liang, Feng, Shang, Haibo, Mense, Martin, Suto, Mark J., Bedwell, David M., Rowe, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114449/
https://ncbi.nlm.nih.gov/pubmed/27104944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201601-0154OC
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