Učitavanje...
Novel Correctors and Potentiators Enhance Translational Readthrough in CFTR Nonsense Mutations
Premature-termination codons (PTCs) in CFTR (cystic fibrosis [CF] transmembrane conductance regulator) result in nonfunctional CFTR protein and are the proximate cause of ∼11% of CF-causing alleles, for which no treatments exist. The CFTR corrector lumacaftor and the potentiator ivacaftor improve CF...
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| Izdano u: | Am J Respir Cell Mol Biol |
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| Glavni autori: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Thoracic Society
2021
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8086047/ https://ncbi.nlm.nih.gov/pubmed/33616476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2019-0291OC |
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