Discovery of Clinically Approved Agents That Promote Suppression of Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations

Rationale: Premature termination codons (PTCs) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF). Several agents are known to suppress PTCs but are poorly efficacious or toxic. Objectives: To determine whether there are clinically available agents that...

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Publicado en:Am J Respir Crit Care Med
Main Authors: Mutyam, Venkateshwar, Du, Ming, Xue, Xiaojiao, Keeling, Kim M., White, E. Lucile, Bostwick, J. Robert, Rasmussen, Lynn, Liu, Bo, Mazur, Marina, Hong, Jeong S., Falk Libby, Emily, Liang, Feng, Shang, Haibo, Mense, Martin, Suto, Mark J., Bedwell, David M., Rowe, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado: American Thoracic Society 2016
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114449/
https://ncbi.nlm.nih.gov/pubmed/27104944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201601-0154OC
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