Synthetic Aminoglycosides Efficiently Suppress Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations and Are Enhanced by Ivacaftor

New drugs are needed to enhance premature termination codon (PTC) suppression to treat the underlying cause of cystic fibrosis (CF) and other diseases caused by nonsense mutations. We tested new synthetic aminoglycoside derivatives expressly developed for PTC suppression in a series of complementary...

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Bibliografski detalji
Glavni autori: Xue, Xiaojiao, Mutyam, Venkateshwar, Tang, Liping, Biswas, Silpak, Du, Ming, Jackson, Laura A., Dai, Yanying, Belakhov, Valery, Shalev, Moran, Chen, Fuquan, Schacht, Jochen, J. Bridges, Robert, Baasov, Timor, Hong, Jeong, Bedwell, David M., Rowe, Steven M.
Format: Artigo
Jezik:Inglês
Izdano: American Thoracic Society 2014
Teme:
Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068923/
https://ncbi.nlm.nih.gov/pubmed/24251786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0282OC
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