Attenuation of Nonsense-Mediated mRNA Decay Enhances In Vivo Nonsense Suppression

Nonsense suppression therapy is an approach to treat genetic diseases caused by nonsense mutations. This therapeutic strategy pharmacologically suppresses translation termination at Premature Termination Codons (PTCs) in order to restore expression of functional protein. However, the process of Nons...

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Hauptverfasser: Keeling, Kim M., Wang, Dan, Dai, Yanying, Murugesan, Srinivasan, Chenna, Balachandra, Clark, Jeremy, Belakhov, Valery, Kandasamy, Jeyakumar, Velu, Sadanandan E., Baasov, Timor, Bedwell, David M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622682/
https://ncbi.nlm.nih.gov/pubmed/23593225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060478
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