Increased Selectivity towards Cytoplasmic versus Mitochondrial Ribosome Confers Improved Efficiency of Synthetic Aminoglycosides in Fixing Damaged Genes: A Strategy for Treatment of Genetic Diseases Caused by Nonsense Mutations

Compelling evidence is now available that gentamicin and geneticin (G418) can induce mammalian ribosome to suppress disease-causing nonsense mutations and partially restore the expression of functional proteins. However, toxicity and relative lack of efficacy at subtoxic doses limit the use of genta...

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Main Authors: Kandasamy, Jeyakumar, Atia-Glikin, Dana, Shulman, Eli, Shapira, Katya, Shavit, Michal, Belakhov, Valery, Baasov, Timor
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542475/
https://ncbi.nlm.nih.gov/pubmed/23148581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3012992
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