Designer Aminoglycosides That Selectively Inhibit Cytoplasmic Rather than Mitochondrial Ribosomes Show Decreased Ototoxicity: A STRATEGY FOR THE TREATMENT OF GENETIC DISEASES

There is compelling evidence that aminoglycoside (AG) antibiotics can induce the mammalian ribosome to suppress disease-causing nonsense mutations and partially restore the expression of functional proteins. However, prolonged AG treatment can cause detrimental side effects in patients, including mo...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Shulman, Eli, Belakhov, Valery, Wei, Gao, Kendall, Ann, Meyron-Holtz, Esther G., Ben-Shachar, Dorit, Schacht, Jochen, Baasov, Timor
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900975/
https://ncbi.nlm.nih.gov/pubmed/24302717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.533588
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados