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Characterization of new-generation aminoglycoside promoting premature termination codon readthrough in cancer cells
Nonsense mutations, generating premature termination codons (PTCs), account for 10% to 30% of the mutations in tumor suppressor genes. Nonsense translational suppression, induced by small molecules including gentamicin and G418, has been suggested as a potential therapy to counteract the deleterious...
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| 出版年: | RNA Biol |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Taylor & Francis
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5367250/ https://ncbi.nlm.nih.gov/pubmed/28145797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2017.1285480 |
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