Characterization of new-generation aminoglycoside promoting premature termination codon readthrough in cancer cells

Nonsense mutations, generating premature termination codons (PTCs), account for 10% to 30% of the mutations in tumor suppressor genes. Nonsense translational suppression, induced by small molecules including gentamicin and G418, has been suggested as a potential therapy to counteract the deleterious...

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Vydáno v:RNA Biol
Hlavní autoři: Bidou, Laure, Bugaud, Olivier, Belakhov, Valery, Baasov, Timor, Namy, Olivier
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367250/
https://ncbi.nlm.nih.gov/pubmed/28145797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2017.1285480
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