Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54

Certain aminoglycosides are capable of inducing “translational readthrough” of premature termination codons (PTCs). However, toxicity and relative lack of efficacy deter treatment with clinically available aminoglycosides for genetic diseases caused by PTCs, including cystic fibrosis (CF). Using a s...

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Détails bibliographiques
Auteurs principaux: Rowe, Steven M., Sloane, Peter, Tang, Li Ping, Backer, Kyle, Mazur, Marina, Buckley-Lanier, Jessica, Nudelman, Igor, Belakhov, Valery, Bebok, Zsuzsa, Schwiebert, Erik, Baasov, Timor, Bedwell, David M.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204584/
https://ncbi.nlm.nih.gov/pubmed/21779978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-011-0787-6
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