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Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54

Certain aminoglycosides are capable of inducing “translational readthrough” of premature termination codons (PTCs). However, toxicity and relative lack of efficacy deter treatment with clinically available aminoglycosides for genetic diseases caused by PTCs, including cystic fibrosis (CF). Using a s...

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主要な著者: Rowe, Steven M., Sloane, Peter, Tang, Li Ping, Backer, Kyle, Mazur, Marina, Buckley-Lanier, Jessica, Nudelman, Igor, Belakhov, Valery, Bebok, Zsuzsa, Schwiebert, Erik, Baasov, Timor, Bedwell, David M.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204584/
https://ncbi.nlm.nih.gov/pubmed/21779978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-011-0787-6
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