Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54

Certain aminoglycosides are capable of inducing “translational readthrough” of premature termination codons (PTCs). However, toxicity and relative lack of efficacy deter treatment with clinically available aminoglycosides for genetic diseases caused by PTCs, including cystic fibrosis (CF). Using a s...

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Detalhes bibliográficos
Main Authors: Rowe, Steven M., Sloane, Peter, Tang, Li Ping, Backer, Kyle, Mazur, Marina, Buckley-Lanier, Jessica, Nudelman, Igor, Belakhov, Valery, Bebok, Zsuzsa, Schwiebert, Erik, Baasov, Timor, Bedwell, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204584/
https://ncbi.nlm.nih.gov/pubmed/21779978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-011-0787-6
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