Novel small molecules potentiate premature termination codon readthrough by aminoglycosides

Nonsense mutations introduce premature termination codons and underlie 11% of genetic disease cases. High concentrations of aminoglycosides can restore gene function by eliciting premature termination codon readthrough but with low efficiency. Using a high-throughput screen, we identified compounds...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:Nucleic Acids Res
Main Authors: Baradaran-Heravi, Alireza, Balgi, Aruna D., Zimmerman, Carla, Choi, Kunho, Shidmoossavee, Fahimeh S., Tan, Jason S., Bergeaud, Célia, Krause, Alexandra, Flibotte, Stéphane, Shimizu, Yoko, Anderson, Hilary J., Mouly, Vincent, Jan, Eric, Pfeifer, Tom, Jaquith, James B., Roberge, Michel
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2016
Ábhair:
Chemical Biology and Nucleic Acid Chemistry
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001621/
https://ncbi.nlm.nih.gov/pubmed/27407112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw638
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla