Novel small molecules potentiate premature termination codon readthrough by aminoglycosides

Nonsense mutations introduce premature termination codons and underlie 11% of genetic disease cases. High concentrations of aminoglycosides can restore gene function by eliciting premature termination codon readthrough but with low efficiency. Using a high-throughput screen, we identified compounds...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nucleic Acids Res
Egile Nagusiak: Baradaran-Heravi, Alireza, Balgi, Aruna D., Zimmerman, Carla, Choi, Kunho, Shidmoossavee, Fahimeh S., Tan, Jason S., Bergeaud, Célia, Krause, Alexandra, Flibotte, Stéphane, Shimizu, Yoko, Anderson, Hilary J., Mouly, Vincent, Jan, Eric, Pfeifer, Tom, Jaquith, James B., Roberge, Michel
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2016
Gaiak:
Chemical Biology and Nucleic Acid Chemistry
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001621/
https://ncbi.nlm.nih.gov/pubmed/27407112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw638
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