Novel small molecules potentiate premature termination codon readthrough by aminoglycosides

Nonsense mutations introduce premature termination codons and underlie 11% of genetic disease cases. High concentrations of aminoglycosides can restore gene function by eliciting premature termination codon readthrough but with low efficiency. Using a high-throughput screen, we identified compounds...

全面介紹

Na minha lista:
書目詳細資料
發表在:Nucleic Acids Res
Main Authors: Baradaran-Heravi, Alireza, Balgi, Aruna D., Zimmerman, Carla, Choi, Kunho, Shidmoossavee, Fahimeh S., Tan, Jason S., Bergeaud, Célia, Krause, Alexandra, Flibotte, Stéphane, Shimizu, Yoko, Anderson, Hilary J., Mouly, Vincent, Jan, Eric, Pfeifer, Tom, Jaquith, James B., Roberge, Michel
格式: Artigo
語言:Inglês
出版: Oxford University Press 2016
主題:
Chemical Biology and Nucleic Acid Chemistry
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001621/
https://ncbi.nlm.nih.gov/pubmed/27407112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw638
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍