Effect of small molecule eRF3 degraders on premature termination codon readthrough

Premature termination codon (PTC) readthrough is considered a potential treatment for genetic diseases caused by nonsense mutations. High concentrations of aminoglycosides induce low levels of PTC readthrough but also elicit severe toxicity. Identifying compounds that enhance PTC readthrough by amin...

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Detaylı Bibliyografya
Yayımlandı:Nucleic Acids Res
Asıl Yazarlar: Baradaran-Heravi, Alireza, Balgi, Aruna D, Hosseini-Farahabadi, Sara, Choi, Kunho, Has, Cristina, Roberge, Michel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2021
Konular:
Chemical Biology and Nucleic Acid Chemistry
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053119/
https://ncbi.nlm.nih.gov/pubmed/33764477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab194
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