Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough

Premature termination codons (PTC) cause over 10% of genetic disease cases. Some aminoglycosides that bind to the ribosome decoding center can induce PTC readthrough and restore low levels of full-length functional proteins. However, concomitant inhibition of protein synthesis limits the extent of P...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Hosseini-Farahabadi, Sara, Baradaran-Heravi, Alireza, Zimmerman, Carla, Choi, Kunho, Flibotte, Stephane, Roberge, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8118496/
https://ncbi.nlm.nih.gov/pubmed/33939688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001221
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