Designer Aminoglycosides That Selectively Inhibit Cytoplasmic Rather than Mitochondrial Ribosomes Show Decreased Ototoxicity: A STRATEGY FOR THE TREATMENT OF GENETIC DISEASES

There is compelling evidence that aminoglycoside (AG) antibiotics can induce the mammalian ribosome to suppress disease-causing nonsense mutations and partially restore the expression of functional proteins. However, prolonged AG treatment can cause detrimental side effects in patients, including mo...

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Bibliografiske detaljer
Main Authors: Shulman, Eli, Belakhov, Valery, Wei, Gao, Kendall, Ann, Meyron-Holtz, Esther G., Ben-Shachar, Dorit, Schacht, Jochen, Baasov, Timor
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900975/
https://ncbi.nlm.nih.gov/pubmed/24302717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.533588
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