Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency

The nonhomologous DNA end-joining (NHEJ) pathway is a key mechanism for repairing dsDNA breaks that occur often in eukaryotic cells. In the simplest model, these breaks are first recognized by Ku, which then interacts with other NHEJ proteins to improve their affinity at DNA ends. These include DNA-...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Chang, Howard H. Y., Watanabe, Go, Gerodimos, Christina A., Ochi, Takashi, Blundell, Tom L., Jackson, Stephen P., Lieber, Michael R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2016
Konular:
DNA and Chromosomes
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114395/
https://ncbi.nlm.nih.gov/pubmed/27703001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.752329
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