Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency

The nonhomologous DNA end-joining (NHEJ) pathway is a key mechanism for repairing dsDNA breaks that occur often in eukaryotic cells. In the simplest model, these breaks are first recognized by Ku, which then interacts with other NHEJ proteins to improve their affinity at DNA ends. These include DNA-...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Chang, Howard H. Y., Watanabe, Go, Gerodimos, Christina A., Ochi, Takashi, Blundell, Tom L., Jackson, Stephen P., Lieber, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114395/
https://ncbi.nlm.nih.gov/pubmed/27703001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.752329
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