The novel mitochondria-targeted hydrogen sulfide (H(2)S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro

The development of diabetic vascular complications is initiated, at least in part, by mitochondrial reactive oxygen species (ROS) production in endothelial cells. Hyperglycemia induces superoxide production in the mitochondria and initiates changes in the mitochondrial membrane potential that leads...

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Опубликовано в: :Pharmacol Res
Главные авторы: Gerő, Domokos, Torregrossa, Roberta, Perry, Alexis, Waters, Alicia, Le-Trionnaire, Sophie, Whatmore, Jacqueline L., Wood, Mark, Whiteman, Matthew
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2016
Предметы:
Invited Perspective
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113977/
https://ncbi.nlm.nih.gov/pubmed/27565382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2016.08.019
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