AP39, a mitochondrially- targeted hydrogen sulfide donor, exerts protective effects in renal epithelial cells subjected to oxidative stress in vitro and in acute renal injury in vivo

Eitemau Tebyg

• AP39 [10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl)phenoxy)decyl) triphenylphosphonium bromide], a mitochondrially targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro
  gan: Szczesny, Bartosz, et al.
  Cyhoeddwyd: (2014)
• Hydrogen sulfide attenuates cytokine production through the modulation of chromatin remodeling
  gan: RIOS, ESTER C.S., et al.
  Cyhoeddwyd: (2015)
• Mitochondria-targeted hydrogen sulfide donor AP39 improves neurological outcomes after cardiac arrest in mice
  gan: Ikeda, Kohei, et al.
  Cyhoeddwyd: (2015)
• Role of endogenous and exogenous nitric oxide, carbon monoxide and hydrogen sulfide in HCT116 colon cancer cell proliferation
  gan: Oláh, Gabor, et al.
  Cyhoeddwyd: (2017)
• The novel mitochondria-targeted hydrogen sulfide (H(2)S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro
  gan: Gerő, Domokos, et al.
  Cyhoeddwyd: (2016)