AP39 [10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl)phenoxy)decyl) triphenylphosphonium bromide], a mitochondrially targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro

The purpose of the current study was to investigate the effect of the recently synthesized mitochondrially-targeted H(2)S donor, AP39 [10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl)phenoxy)decyl) triphenylphosphonium bromide], on bioenergetics, viability, and mitochondrial DNA integrity in bEnd.3 murine...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nitric Oxide
Prif Awduron: Szczesny, Bartosz, Módis, Katalin, Yanagi, Kazunori, Coletta, Ciro, Le Trionnaire, Sophie, Wood, Mark E., Whiteman, Matthew, Szabo, Csaba
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4225488/
https://ncbi.nlm.nih.gov/pubmed/24755204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.niox.2014.04.008
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