AP39 [10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl)phenoxy)decyl) triphenylphosphonium bromide], a mitochondrially targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro

The purpose of the current study was to investigate the effect of the recently synthesized mitochondrially-targeted H(2)S donor, AP39 [10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl)phenoxy)decyl) triphenylphosphonium bromide], on bioenergetics, viability, and mitochondrial DNA integrity in bEnd.3 murine...

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Detalhes bibliográficos
Publicado no:Nitric Oxide
Main Authors: Szczesny, Bartosz, Módis, Katalin, Yanagi, Kazunori, Coletta, Ciro, Le Trionnaire, Sophie, Wood, Mark E., Whiteman, Matthew, Szabo, Csaba
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4225488/
https://ncbi.nlm.nih.gov/pubmed/24755204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.niox.2014.04.008
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