AP39 [10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl)phenoxy)decyl) triphenylphosphonium bromide], a mitochondrially targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro

The purpose of the current study was to investigate the effect of the recently synthesized mitochondrially-targeted H(2)S donor, AP39 [10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl)phenoxy)decyl) triphenylphosphonium bromide], on bioenergetics, viability, and mitochondrial DNA integrity in bEnd.3 murine...

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Publicat a:Nitric Oxide
Autors principals: Szczesny, Bartosz, Módis, Katalin, Yanagi, Kazunori, Coletta, Ciro, Le Trionnaire, Sophie, Wood, Mark E., Whiteman, Matthew, Szabo, Csaba
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4225488/
https://ncbi.nlm.nih.gov/pubmed/24755204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.niox.2014.04.008
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