Mitochondrial-Targeted Decyl-Triphenylphosphonium Enhances 2-Deoxy-D-Glucose Mediated Oxidative Stress and Clonogenic Killing of Multiple Myeloma Cells

Therapeutic advances have markedly prolonged overall survival in multiple myeloma (MM) but the disease currently remains incurable. In a panel of MM cell lines (MM.1S, OPM-2, H929, and U266), using CD138 immunophenotyping, side population staining, and stem cell-related gene expression, we demonstra...

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Veröffentlicht in:PLoS One
Hauptverfasser: Schibler, Jeanine, Tomanek-Chalkley, Ann M., Reedy, Jessica L., Zhan, Fenghuang, Spitz, Douglas R., Schultz, Michael K., Goel, Apollina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5130279/
https://ncbi.nlm.nih.gov/pubmed/27902770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167323
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